Dr. Utpreksha Vaish
PhD Postdoctoral Associate Sylvester Comprehensive Cancer Center
Department of Surgery
School of Medicine
University of Miami
Currently employed as Postdoctoral Associate (24th April 2019- Present) at Department of Surgery, Sylvester Comprehensive Cancer Center, University of Miami-Miller School of Medicine, Miami, FL, USA and working on immune-oncological and translational aspect of PDAC (Pancreatic Ductal adenocarcinoma).Worked as Bioassay Analyst (29th September 2017- 18th April 2019) at Therapeutic Monoclonal Antibody Laboratory, National Institute of Biologicals, Ministry of Health and Family Welfare, India. PhD dissertation entitled “Investigation of molecular mechanisms involved in Vitiligo aetiopathogenesis” was successfully pursued and defended (January 2019) under supervision of Dr. Rajni Rani at National Institute of Immunology (NII), New Delhi, India.Qualified Integrated M.Sc.-PhD entrance, 2010 conducted by Dr. B. R. Ambedkar Center for Biomedical Research (ACBR), University of Delhi. Qualified PhD Entrance Examination, 2012 conducted by National Institute of Immunology (NII) and awarded PhD fellowship for same.
M.Sc. Dissertation: “To explicate the biochemical efficacy of Novel Cox-2 inhibitor” in context of Pancreatic Cancer, under guidance of Dr. Madhu Chopra, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India
Method validation of in vitro bioassay for Anti-TNFα therapeutic monoclonal antibody, Adalimumab biosimilars and Etanercept (fusion protein) biosimilars for process of batch release at National Institute of Biologicals, Noida, India.
Presence of Auto-reactive, MHC class-I restricted, Calcium Sensing Receptor (CaSR) specific CD8+ T cells in Idiopathic Hypoparathyroidism. Samrina Mahtab*, Utpreksha Vaish*, Soma Saha, Archana Singh, Ravinder Goswami, Rajni Rani. The Journal of Clinical Endocrinology & Metabolism (November 02, 2016). Micro RNAs upregulated in Vitiligo skin play an important role in its aetiopathogenesis by altering TRP1 expression and keratinocyte-melanocytes crosstalk. Utpreksha Vaish, Avinash A Kumar, Swati Varshney, Shreya Ghosh, Shantanu Sengupta, Chandni Sood, Hemanta K Kar, Pankaj Sharma, Vivek T Natarajan, Rajesh S Gokhale, Rajni Rani. Scientific Reports (July 12, 2019)
The pathophysiology of Vitiligo, an acquired and multifactorial autoimmune disorder characterized by regions of depigmented skin.
Microarray analysis for lesional and non-lesional epidermal samples from vitiligo patients wherein pathway enrichment revealed significantly regulated pathway in vitiligo lesional epidermis.
biomolecule and investigated its expression pattern in normal human epidermal melanocytes & keratinocytes and lesional vs. non-lesional epidermis and studied its role in melanogenesis and oxidative stress pathway, two important arms of vitiligo pathogenesis.